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Started:  April 2015 

we offer 
 
8 MD fellowships
(1 year; € 735/m) 

read more 

06.11.2017 - 08.11.2017

Hallmarks of Skin Cancer Conference (HoSC) - DKFZ, Heidelberg

For further details please see
http://www.dkfz.de/en/hosc2017/index.html

Workshop "Biostatistics", Dr. Marietta Kirchner (IMBI, Universität Heidelberg)
When: 27.09.2017- 28.09.2017
Where: Alte Brauerei, University Medical Center Mannheim, seminar room S21 and S22

Publications

2017

Baum, C., Weiss, C., Gebhardt, C., Utikal, J., Marx, A., Koenen, W., Géraud, C., 2017. Sentinel node metastasis mitotic rate (SN-MMR) as a prognostic indicator of rapidly progressing disease in patients with sentinel node-positive melanomas. Int. J. Cancer 140, 1907–1917. doi:10.1002/ijc.30563

 

Géraud, C.*, Koch, P.-S.*, Zierow, J.*, Klapproth, K., Busch, K., Olsavszky, V., Leibing, T., Demory, A., Ulbrich, F., Diett, M., Singh, S., Sticht, C., Breitkopf-heinlein, K., Richter, K., Karppinen, S., Pihlajaniemi, T., Arnold, B., Rodewald, H., Augustin, H.G., Schledzewski, K., Goerdt, S., 2017. GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. Journal of Clinical Investigation 127, 1099–1114

 

 

Koch, P.-S.*, Olsavszky, V.*, Ulbrich, F., Sticht, C., Demory, A., Leibing, T., Henzler, T., Meyer, M., Zierow, J., Schneider, S., Breitkopf-Heinlein, K., Gaitantzi, H., Spencer-Dene, B., Arnold, B., Klapproth, K., Schledzewski, K., Goerdt, S., Géraud, C., 2017. Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood 129, 415–420. doi:10.1182/blood-2016-07-729822

 

Olsavszky V, Ulbrich F, Singh S, Diett M, Sticht C, Schmid CD, Zierow J, Wohlfeil SA, Schledzewski K, Dooley S, Gaitantzi H, Breitkopf-Heinlein K, Géraud C, Goerdt S, Koch PS:  GATA4 and LMO3 balance angiocrine signalling and autocrine inflammatory activation by BMP2 in liver sinusoidal endothelial cells. Gene. 2017 Jun 29. pii: S0378-1119(17)30501-2. doi: 10.1016/j.gene.2017.06.051

 

Sedlmeier, G., Sleeman, J.P., 2017. Extracellular regulation of BMP signaling : welcome to the matrix. Biochem. Soc. Trans. 45, 173–181. doi:10.1042/BST20160263

 

2016

Desch, A., Gebhardt, C., Utikal, J., Schneider, S.W., 2016. D-dimers in malignant melanoma: Association with prognosis and dynamic variation in disease progress. Int. J. Cancer 1–23. doi:10.1002/ijc.30498

 

Fehrenbach, S., Novak, D., Bernhardt, M., Larribere, L., Boukamp, P., Umansky, V., Utikal, J., 2016. Loss of tumorigenic potential upon transdifferentiation from keratinocytic into melanocytic lineage. Sci. Rep. 6, 1–12. doi:10.1038/srep28891

 

Goertz, L.*, Schneider, S.W.*, Desch, A., Mayer, F.T., Koett, J., Nowak, K., Karampinis, I., Bohlmann, M.K., Umansky, V., Bauer, A.T., 2016. Heparins that block VEGF-A-mediated von Willebrand factor fiber generation are potent inhibitors of hematogenous but not lymphatic metastasis. Oncotarget 7, 68527–45. doi:10.18632/oncotarget.11832

 

Hughes, M.A., Powley, I.R., Jukes-Jones, R., Horn, S., Feoktistova, M., Fairall, L., Schwabe, J.W.R., Leverkus, M., Cain, K., MacFarlane, M., 2016. Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate. Mol. Cell 61, 834–849. doi:10.1016/j.molcel.2016.02.023

 

Krachulec, J.M., Sedlmeier, G., Thiele, W., Sleeman, J.P., 2016. Footprintless disruption of prosurvival genes in aneuploid cancer cells using CRISPR/Cas9 technology. Biochem. Cell Biol. 94, 289–96. doi:10.1139/bcb-2015-0150

 

Umansky, V., Blattner, C., Fleming, V., Hu, X., Gebhardt, C., Altevogt, P., Utikal, J., 2016. Myeloid-derived suppressor cells and tumor escape from immune surveillance. Semin. Immunopathol. doi:10.1007/s00281-016-0597-6

 

Umansky, V., Blattner, C., Gebhardt, C., Utikal, J., 2016. The Role of Myeloid-Derived Suppressor Cells ( MDSC ) in Cancer Progression. Vaccines 4. doi:10.3390/vaccines4040036

 

Weina, K.*, Wu, H.*, Knappe, N., Orouji, E., Novak, D., Bernhardt, M., Hüser, L., Larribère, L., Umansky, V., Gebhardt, C., Utikal, J., 2016. TGF-β induces SOX2 expression in a time-dependent manner in human melanoma cells. Pigment Cell Melanoma Res. 29, 453–458. doi:10.1111/pcmr.12483

 

2015

Bauer, A.T.*, Suckau, J.*, Frank, K., Desch, A., Goertz, L., Wagner, A.H., Hecker, M., Goerge, T., Umansky, L., Beckhove, P., Utikal, J., Gorzelanny, C., Diaz-valdes, N., Umansky, V., Schneider, S.W., 2015. von Willebrand factor fi bers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans. Blood 125, 3153–3164. doi:10.1182/blood-2014-08-595686.A.T.B.

 

Gebhardt, C., Sevko, A., Jiang, H., Lichtenberger, R., Reith, M., Tarnanidis, K., Holland-Letz, T., Umansky, L., Beckhove, P., Sucker, A., Schadendorf, D., Utikal, J., Umansky, V., 2015. Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab. Clin. cancer Res. 21, 5453–9. doi:10.1158/1078-0432.CCR-15-0676

 

Geserick, P., Wang, J., Schilling, R., Horn, S., Harris, P.A., Bertin, J., Gough, P.J., Feoktistova, M., Leverkus, M., 2015. Absence of RIPK3 predicts necroptosis resistance in malignant melanoma. Cell Death Dis. 6, e1884-12. doi:10.1038/cddis.2015.240

 

 

_: Members of the RTG2099

 

_: Graduate students of the RTG2099

 

*: These authors contributed equally

 

News

Started:  April 2015 

we offer 
 
8 MD fellowships
(1 year; € 735/m) 

read more 

06.11.2017 - 08.11.2017

Hallmarks of Skin Cancer Conference (HoSC) - DKFZ, Heidelberg

For further details please see
http://www.dkfz.de/en/hosc2017/index.html

Workshop "Biostatistics", Dr. Marietta Kirchner (IMBI, Universität Heidelberg)
When: 27.09.2017- 28.09.2017
Where: Alte Brauerei, University Medical Center Mannheim, seminar room S21 and S22