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Started:  April 2015 

we offer 
 
8 MD fellowships
(1 year; € 735/m) 

read more 

Plenary Meeting 2017

When: 11.12.2017, 11.30 am
Where: Dept. Dermatology, Venereology and Allergology, University Medical Center Mannheim, house 27, 4th floor, room 10

1-Week Laboratory Course, WS 2017/2018

Start: 12.12.2017
Where: DKZF, Division Signaling and Functional Genomics (B110), Im Neuenheimer Feld 580, 69120 Heidelberg

Workshop "Scientific Writing", Dr. Sita Schanne (key competencies and university didactics, University of Heidelberg)
When: 05.02.2018-06.02.2018, 9.15-16.00

 

Publications

2017

Baum, C., Weiss, C., Gebhardt, C., Utikal, J., Marx, A., Koenen, W., Géraud, C., 2017. Sentinel node metastasis mitotic rate (SN-MMR) as a prognostic indicator of rapidly progressing disease in patients with sentinel node-positive melanomas. Int. J. Cancer 140, 1907–1917. doi:10.1002/ijc.30563

 

Blattner C., Fleming V., Weber R., Himmelhan B.S., Altevogt P., Gebhardt C., Schulze T.J., Razon H., Hawila E., Wildbaum G., Utikal J., Karin N., Umansky V., 2017. CCR5+ myeloid-derived suppressor cells are enriched and activated in melanoma lesions. Cancer Res. 2017 Oct 31. pii: canres.0348.2017

 

Géraud, C.*, Koch, P.-S.*, Zierow, J.*, Klapproth, K., Busch, K., Olsavszky, V., Leibing, T., Demory, A., Ulbrich, F., Diett, M., Singh, S., Sticht, C., Breitkopf-heinlein, K., Richter, K., Karppinen, S., Pihlajaniemi, T., Arnold, B., Rodewald, H., Augustin, H.G., Schledzewski, K., Goerdt, S., 2017. GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. Journal of Clinical Investigation 127, 1099–1114

 

Horn, S., Hughes, M.A., Schilling, R., Sticht, C., Tenev, T., Ploesser, M., Sprick, M.R., Meier, P., MacFarlane, M., Leverkus, M., 2017. Caspase-10 Negatively Regulates Caspase-8- Mediated Cell Death , Switching the Response to CD95L in Favor of NF- k B Activation and Cell Survival. CellReports 19, 785–797. doi:10.1016/j.celrep.2017.04.010

 
 

Koch, P.-S.*, Olsavszky, V.*, Ulbrich, F., Sticht, C., Demory, A., Leibing, T., Henzler, T., Meyer, M., Zierow, J., Schneider, S., Breitkopf-Heinlein, K., Gaitantzi, H., Spencer-Dene, B., Arnold, B., Klapproth, K., Schledzewski, K., Goerdt, S., Géraud, C., 2017. Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood 129, 415–420. doi:10.1182/blood-2016-07-729822

 

Leibing T., Géraud C., Augustin I., Boutros M., Augustin H.G., Okun J.G., Langhans C.D., Zierow J., Wohlfeil S.A., Olsavszky V., Schledzewski K., Goerdt S., Koch P.S.,2017. Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology. 2017 Oct 23. doi: 10.1002/hep.29613. [Epub ahead of print]

 

Olsavszky, V., Ulbrich, F., Singh, S., Diett, M., Sticht, C., Schmid, C.D., Zierow, J., Wohlfeil, S.A., Schledzewski, K., Dooley, S., Gaitantz, H., Breitkopf-Heinlein, K., Géraud, C., Goerdt, S., Koch, P.S.,2017.  GATA4 and LMO3 balance angiocrine signalling and autocrine inflammatory activation by BMP2 in liver sinusoidal endothelial cells. Gene. 2017 Jun 29. pii: S0378-1119(17)30501-2. doi: 10.1016/j.gene.2017.06.051

 

Sedlmeier, G., Sleeman, J.P., 2017. Extracellular regulation of BMP signaling : welcome to the matrix. Biochem. Soc. Trans. 45, 173–181. doi:10.1042/BST20160263

 

 Desch, A., Gebhardt, C., Utikal, J., Schneider, S.W., 2017. D-dimers in malignant melanoma: Association with prognosis and dynamic variation in disease progress. Int. J. Cancer 1–23. doi:10.1002/ijc.30498

 

2016

Fehrenbach, S., Novak, D., Bernhardt, M., Larribere, L., Boukamp, P., Umansky, V., Utikal, J., 2016. Loss of tumorigenic potential upon transdifferentiation from keratinocytic into melanocytic lineage. Sci. Rep. 6, 1–12. doi:10.1038/srep28891

 

Goertz, L.*, Schneider, S.W.*, Desch, A., Mayer, F.T., Koett, J., Nowak, K., Karampinis, I., Bohlmann, M.K., Umansky, V., Bauer, A.T., 2016. Heparins that block VEGF-A-mediated von Willebrand factor fiber generation are potent inhibitors of hematogenous but not lymphatic metastasis. Oncotarget 7, 68527–45. doi:10.18632/oncotarget.11832

 

Hughes, M.A., Powley, I.R., Jukes-Jones, R., Horn, S., Feoktistova, M., Fairall, L., Schwabe, J.W.R., Leverkus, M., Cain, K., MacFarlane, M., 2016. Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate. Mol. Cell 61, 834–849. doi:10.1016/j.molcel.2016.02.023

 

Krachulec, J.M., Sedlmeier, G., Thiele, W., Sleeman, J.P., 2016. Footprintless disruption of prosurvival genes in aneuploid cancer cells using CRISPR/Cas9 technology. Biochem. Cell Biol. 94, 289–96. doi:10.1139/bcb-2015-0150

 

Umansky, V., Blattner, C., Fleming, V., Hu, X., Gebhardt, C., Altevogt, P., Utikal, J., 2016. Myeloid-derived suppressor cells and tumor escape from immune surveillance. Semin. Immunopathol. doi:10.1007/s00281-016-0597-6

 

Umansky, V., Blattner, C., Gebhardt, C., Utikal, J., 2016. The Role of Myeloid-Derived Suppressor Cells ( MDSC ) in Cancer Progression. Vaccines 4. doi:10.3390/vaccines4040036

 

Weina, K.*, Wu, H.*, Knappe, N., Orouji, E., Novak, D., Bernhardt, M., Hüser, L., Larribère, L., Umansky, V., Gebhardt, C., Utikal, J., 2016. TGF-β induces SOX2 expression in a time-dependent manner in human melanoma cells. Pigment Cell Melanoma Res. 29, 453–458. doi:10.1111/pcmr.12483

 

2015

Bauer, A.T.*, Suckau, J.*, Frank, K., Desch, A., Goertz, L., Wagner, A.H., Hecker, M., Goerge, T., Umansky, L., Beckhove, P., Utikal, J., Gorzelanny, C., Diaz-valdes, N., Umansky, V., Schneider, S.W., 2015. von Willebrand factor fi bers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans. Blood 125, 3153–3164. doi:10.1182/blood-2014-08-595686.A.T.B.

 

Geserick, P., Wang, J., Schilling, R., Horn, S., Harris, P.A., Bertin, J., Gough, P.J., Feoktistova, M., Leverkus, M., 2015. Absence of RIPK3 predicts necroptosis resistance in malignant melanoma. Cell Death Dis. 6, e1884-12. doi:10.1038/cddis.2015.240

 

 

_: Members of the RTG2099

 

_: Graduate students of the RTG2099

 

*: These authors contributed equally

 

News

Started:  April 2015 

we offer 
 
8 MD fellowships
(1 year; € 735/m) 

read more 

Plenary Meeting 2017

When: 11.12.2017, 11.30 am
Where: Dept. Dermatology, Venereology and Allergology, University Medical Center Mannheim, house 27, 4th floor, room 10

1-Week Laboratory Course, WS 2017/2018

Start: 12.12.2017
Where: DKZF, Division Signaling and Functional Genomics (B110), Im Neuenheimer Feld 580, 69120 Heidelberg

Workshop "Scientific Writing", Dr. Sita Schanne (key competencies and university didactics, University of Heidelberg)
When: 05.02.2018-06.02.2018, 9.15-16.00